Phospholipase D: A Novel Major Player in Signal Transduction

Cell Signal. 1998 Jun;10(6):387-97. doi: 10.1016/s0898-6568(97)00197-6.


The role of the mammalian phospholipase D (PLD) in the control of key cellular responses has been recognised for a long time, but only recently have there been the reagents to properly study this very important enzyme in the signalling pathways, linking cell agonists with intracellular targets. With the recent cloning of PLD isoenzymes, their association with low-molecular-weight G proteins, protein kinase C and tyrosine kinases, the availability of antibodies and an understanding of the role of PLD product, phosphatidic acid (PA), in cell physiology, the field is gaining momentum. In this review, we will explore the molecular properties of mammalian PLD and its gene(s), the complexity of this enzyme regulation and the myriad physiological roles for PLD and PA and related metabolic products, with particular emphasis on a role in the activation of NADPH oxidase, or respiratory burst, leading to the generation of oxygen radicals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • NADPH Oxidases / metabolism
  • Phosphatidic Acids / metabolism
  • Phospholipase D / physiology*
  • Respiratory Burst / physiology
  • Signal Transduction / physiology*


  • Phosphatidic Acids
  • NADPH Oxidases
  • Phospholipase D