Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse

Pharmacol Res. 1998 Aug;38(2):107-10. doi: 10.1006/phrs.1998.0338.


The effects of Ocimum sanctum leaf extract on the changes in the concentrations of serum triiodothyronine (T3), thyroxine (T4) and serum cholesterol; in the activities of hepatic glucose-6-phosphatase (G-6-P), superoxide dismutase (SOD) and catalase (CAT); hepatic lipid peroxidation (LPO) and on the changes in the weight of the sex organs were investigated. While the plant extract at the dose of 0.5 g kg-1 body wt. for 15 days significantly decreased serum T4 concentrations, hepatic LPO and G-6-P activity, the activities of endogenous antioxidant enzymes, SOD and CAT were increased by the drug. However, no marked changes were observed in serum T3 level, T3/T4 ratio and in the concentration of serum cholesterol. It appears that Ocimum sanctum leaf extract is antithyroidic as well as antioxidative in nature.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / metabolism
  • Cholesterol / blood
  • Genitalia, Male / anatomy & histology
  • Genitalia, Male / drug effects*
  • India
  • Lipid Peroxidation
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Mice
  • Organ Size / drug effects
  • Plant Extracts / pharmacology
  • Plants, Medicinal*
  • Superoxide Dismutase / metabolism
  • Thyroid Gland / drug effects*
  • Thyroxine / blood
  • Triiodothyronine / blood


  • Plant Extracts
  • Triiodothyronine
  • Cholesterol
  • Catalase
  • Superoxide Dismutase
  • Thyroxine