Norepinephrine-augmenting lipolytic effectors from Astilbe thunbergii rhizomes

J Nat Prod. 1998 Aug;61(8):1006-11. doi: 10.1021/np980107o.

Abstract

An EtOAc-soluble fraction from a 80% Me2CO extract of the rhizomes of Astilbe thunbergii enhanced norepinephrine-induced lipolysis in rat fat cells, while an EtOAc-insoluble fraction had no effect. The active substances isolated from the EtOAc-soluble fraction of the rhizomes were identified as eucryphin (1), bergenin (2), and astilbin (3), which enhanced norepinephrine-induced lipolysis at concentrations of 10-1000 microgram/mL, while they themselves did not cause lipolysis. Furthermore, these compounds slightly stimulated adrenocorticotrophic hormone-induced lipolysis and inhibited insulin-induced lipogenesis from glucose.

MeSH terms

  • Adipocytes / drug effects
  • Adipocytes / metabolism
  • Adrenergic alpha-Agonists / pharmacology*
  • Animals
  • Carbohydrate Sequence
  • China
  • Lipolysis / drug effects*
  • Male
  • Molecular Sequence Data
  • Norepinephrine / pharmacology*
  • Plant Extracts / chemistry
  • Plant Roots / chemistry*
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar
  • Saline Solution, Hypertonic

Substances

  • Adrenergic alpha-Agonists
  • Plant Extracts
  • Saline Solution, Hypertonic
  • Norepinephrine