Cytotoxic sterols from the soft coral Nephthea erecta

C Y Duh; S K Wang; M J Chu; J H Sheu

doi:10.1021/np9800497

Cytotoxic sterols from the soft coral Nephthea erecta

J Nat Prod. 1998 Aug;61(8):1022-4. doi: 10.1021/np9800497.

Authors

C Y Duh¹, S K Wang, M J Chu, J H Sheu

Affiliation

¹ Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. yihduh@nsysu.edu.tw

PMID: 9722490
DOI: 10.1021/np9800497

Abstract

Two new cytotoxic sterols, 24-methylcholesta-5,24(28)-diene-3beta, 15beta,19-triol (1) and 24-methylcholesta-5,24(28)-diene-3beta, 19-diol-7-one (2), as well as four cytotoxic sterols, 24-methylcholesta-5,24(28)-diene-3beta,19-diol (3), 24-methylcholesta-5,24(28)-diene-3beta,19-diol-7beta-mono aetate (4), 24-methylcholesta-5,24(28)-diene-3beta,7beta,19-triol (5), and 24-methylcholesta-24(28)-ene-3beta,5alpha,6beta,19-tet raol (6), have been isolated from the soft coral Nephthea erecta. The structures of compounds 1 and 2 were determined by spectral analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cnidaria / chemistry*
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Sterols / isolation & purification*
Sterols / pharmacology
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Sterols