Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis

S Kodani; K Ishida; M Murakami

doi:10.1021/np980106w

Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis

J Nat Prod. 1998 Aug;61(8):1046-8. doi: 10.1021/np980106w.

Authors

S Kodani¹, K Ishida, M Murakami

Affiliation

¹ Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 9722497
DOI: 10.1021/np980106w

Abstract

Aeruginosin 103-A was isolated from the cultured freshwater cyanobacterium Microcystis viridis(NIES-103). Its structure was elucidated to be 1 on the basis of 2D NMR data. This linear peptide inhibited thrombin, with an IC50 of 9.0 microgram/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Microcystis / chemistry*
Oligopeptides / isolation & purification*
Oligopeptides / pharmacology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Thrombin / antagonists & inhibitors*

Substances

Oligopeptides
aeruginosin 103-A
Thrombin