Aeruginosin 103-A, a thrombin inhibitor from the cyanobacterium Microcystis viridis

J Nat Prod. 1998 Aug;61(8):1046-8. doi: 10.1021/np980106w.

Abstract

Aeruginosin 103-A was isolated from the cultured freshwater cyanobacterium Microcystis viridis(NIES-103). Its structure was elucidated to be 1 on the basis of 2D NMR data. This linear peptide inhibited thrombin, with an IC50 of 9.0 microgram/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Microcystis / chemistry*
  • Oligopeptides / isolation & purification*
  • Oligopeptides / pharmacology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Thrombin / antagonists & inhibitors*

Substances

  • Oligopeptides
  • aeruginosin 103-A
  • Thrombin