HLA-peptide tetrameric complexes

Curr Opin Immunol. 1998 Aug;10(4):393-6. doi: 10.1016/s0952-7915(98)80110-6.


HLA-peptide tetrameric complexes allow the direct ex vivo visualisation of antigen-specific CD8+ T cells and natural killer cells by flow cytometry. Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function.

Publication types

  • Review

MeSH terms

  • HLA Antigens / immunology*
  • Humans
  • Peptides / immunology*


  • HLA Antigens
  • Peptides