Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells

Curr Opin Immunol. 1998 Aug;10(4):444-9. doi: 10.1016/s0952-7915(98)80119-2.


The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Chronic Disease
  • Humans
  • Lymphocyte Activation
  • Vaccination*
  • Viral Vaccines / therapeutic use*
  • Virus Diseases / drug therapy
  • Virus Diseases / immunology*


  • Viral Vaccines