Listeria monocytogenes as a probe to study cell-mediated immunity

Curr Opin Immunol. 1998 Aug;10(4):450-8. doi: 10.1016/s0952-7915(98)80120-9.


The intracellular bacterium Listeria monocytogenes continues to serve as a model to define general paradigms of cell-mediated immunity. Genetic manipulations of the bacterium and its murine host have allowed us to begin dissecting the intricate interactions between this bacterium and the immune system. As a result, we have gained new insights into the mechanisms of immune surveillance, achieved better understanding of bacterial tactics for immune evasion and developed novel strategies in vaccine development.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Apoptosis
  • Immunity, Cellular / immunology*
  • Listeria monocytogenes / immunology*