Human ocular aldehyde dehydrogenase isozymes: distribution and properties as major soluble proteins in cornea and lens

J Exp Zool. 1998 Sep-Oct;282(1-2):12-7.


Human aldehyde dehydrogenase isozymes (ALDHs; EC exhibit very high levels of activity in anterior eye tissues. Human corneal ALDH1 and ALDH3 isozymes are present as major soluble proteins (3% and 5%, respectively, of corneal soluble protein) and may play major roles in protecting the cornea against ultraviolet radiation (UVR)-induced tissue damage, as well as contributing directly to ultraviolet B (UV-B) photoreception. The human lens exhibits high levels of ALDH1 activity (1-2% of lens-soluble protein) and lower levels of ALDH3 activity. Kinetic analyses support a role for these enzymes in the metabolism of peroxidic aldehydes, which have been reported in ocular tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Dehydrogenase / isolation & purification
  • Aldehyde Dehydrogenase / metabolism*
  • Aldehydes / metabolism
  • Cornea / enzymology*
  • Humans
  • Isoenzymes / isolation & purification
  • Isoenzymes / metabolism*
  • Kinetics
  • Lens, Crystalline / enzymology*
  • Photoreceptor Cells / physiology
  • Ultraviolet Rays / adverse effects


  • Aldehydes
  • Isoenzymes
  • Aldehyde Dehydrogenase