Adsorption of technetium-99m tetrofosmin and technetium-99m furifosmin on plastic syringes

Eur J Nucl Med. 1998 Sep;25(9):1333-5. doi: 10.1007/s002590050304.


Some groups have reported that adsorption of radiopharmaceuticals on disposable plastic syringes can reach levels of almost 50%. This high loss of radioactivity stimulated us to carry out similar studies. Our measurements were done in combination with patient studies. Therefore, we used 2-ml syringes, all of the same brand. The radioactivity in the syringe was measured immediately before and after injection. a total of 500-600 MBq technetium-99m labelled tetrofosmin or technetium-99m furifosmin was administered to 48 patients using four different injection techniques (n = 6 for each technique with each tracer): with needles, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer; with butterflies, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer. Neither in syringes nor in needles or butterflies did more than 7% of the initial radioactivity remain. The entire residual activity in syringe plus needle or syringe plus butterfly together never exceeded the 9% limit. Furthermore, in a pilot study we measured the remaining radioactivity in the vial; here, too, we found no more than 14% of total radioactivity. These findings indicate that total retention of radioactivity during elution and application of 99mTc-tetrofosmin and 99mTc-furifosmin with material used in our setting does not approach relevant amounts.

MeSH terms

  • Adsorption
  • Furans*
  • Humans
  • Needles
  • Organophosphorus Compounds*
  • Organotechnetium Compounds*
  • Pilot Projects
  • Plastics
  • Radiopharmaceuticals*
  • Syringes*


  • Furans
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Plastics
  • Radiopharmaceuticals
  • technetium Tc 99m Q12
  • technetium tc-99m tetrofosmin