Acute pancreatitis following lisinopril rechallenge

Am J Emerg Med. 1998 Sep;16(5):523-4. doi: 10.1016/s0735-6757(98)90009-2.


Acute pancreatitis has many causes, the most common being biliary tract disease and alcoholism. Other etiologic categories are abdominal trauma; postoperative, including endoscopic retrograde cholangiopancreatography; metabolic, including hypercalcemia and hypertriglyceridemia; Infectious; idiopathic; and drug-induced. The drugs most strongly associated with pancreatitis are sulfonamides, thiazides, furosemide, estrogens, and tetracycline. Approximately 100 cases of pancreatitis induced by angiotensin-converting enzyme inhibitor have been reported to the US Food and Drug Administration, of which about 20 involved lisinopril. We report a case of pancreatitis occurring only 3 hours after intake of lisinopril by a man without other risk factors for the illness. The patient had experienced a similar but less severe reaction to this medication 3 months earlier. This case probably represents the first time a patient was rechallenged with lisinopril and had a more significant adverse reaction.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Antihypertensive Agents / adverse effects*
  • Emergency Treatment*
  • Humans
  • Hypertension / drug therapy
  • Lisinopril / adverse effects*
  • Male
  • Pancreatitis / chemically induced*


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Lisinopril