Multiple synchronous lung cancers and atypical adenomatous hyperplasia in Li-Fraumeni syndrome

Histopathology. 1998 Jul;33(1):52-4. doi: 10.1046/j.1365-2559.1998.00439.x.


Aim: We report a patient with Li-Fraumeni syndrome who developed multiple synchronous primary lung cancers together with atypical adenomatous hyperplasia, and discuss the pathogenesis of the lesions.

Case details: A 57-year-old woman with Li-Fraumeni syndrome and a history of smoking was diagnosed as having multiple synchronous primary lung tumours, all of which were treated by surgical excision. Histological examination showed three separate well-differentiated adenocarcinomas and a single focus of atypical adenomatous hyperplasia. A constitutional mutation of the p53 gene had been identified, both in this patient and other members of her family.

Conclusion: Multiple synchronous primary lung tumours have not been reported before in association with this syndrome. With both smoking and Li-Fraumeni syndrome known to be associated with mutations in the p53 gene, a cumulative effect is suggested in this patient.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology*
  • Adenoma / metabolism
  • Adenoma / pathology*
  • Female
  • Humans
  • Hyperplasia / metabolism
  • Hyperplasia / pathology
  • Li-Fraumeni Syndrome / metabolism
  • Li-Fraumeni Syndrome / pathology*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology*
  • Middle Aged
  • Neoplasms, Multiple Primary / metabolism
  • Neoplasms, Multiple Primary / pathology
  • Precancerous Conditions
  • Tumor Suppressor Protein p53 / metabolism


  • Tumor Suppressor Protein p53