Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia

Chest. 1998 Aug;114(2):641-2. doi: 10.1378/chest.114.2.641.


The following describes a patient on a stable regimen of warfarin who developed severe hypoprothrombinemia and bleeding 4 weeks after starting gemfibrozil. Despite a warning by the manufacturer, only one report of this interaction has been published in the literature. This interaction may be overlooked by clinicians, which may result in a serious bleeding risk for patients on warfarin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticoagulants / adverse effects*
  • Drug Interactions
  • Follow-Up Studies
  • Gemfibrozil / adverse effects*
  • Hemorrhage / chemically induced
  • Humans
  • Hyperlipidemias / drug therapy
  • Hypolipidemic Agents / adverse effects*
  • Hypoprothrombinemias / chemically induced*
  • Male
  • Thrombophlebitis / drug therapy
  • Warfarin / adverse effects*


  • Anticoagulants
  • Hypolipidemic Agents
  • Warfarin
  • Gemfibrozil