Cerebrospinal fluid protein changes in multiple sclerosis after dental amalgam removal

Altern Med Rev. 1998 Aug;3(4):295-300.


A relationship between multiple sclerosis (MS) and dental silver-mercury fillings has been suggested by some investigators, but never proven. This study documents objective biochemical changes following the removal of these fillings along with other dental materials, utilizing a new health care model of multidisciplinary planning and treatment. The dramatic changes in photolabeling of cerebrospinal fluid (CSF) proteins following these dental interventions suggest CSF photolabeling may serve as an objective biomarker for monitoring MS. The clear-cut character of these changes should also encourage more research to better define this possible association between dental mercury and MS.

MeSH terms

  • Cerebrospinal Fluid Proteins / drug effects
  • Cerebrospinal Fluid Proteins / isolation & purification*
  • Dental Amalgam / adverse effects*
  • Dental Restoration, Permanent / adverse effects
  • Electrophoresis
  • Humans
  • Mercury / adverse effects*
  • Multiple Sclerosis / cerebrospinal fluid*
  • Photolysis


  • Cerebrospinal Fluid Proteins
  • Dental Amalgam
  • Mercury