Sensitization of cells to ionizing radiation by chlorin e6Na

Radiat Oncol Investig. 1998;6(4):151-6. doi: 10.1002/(SICI)1520-6823(1998)6:4<151::AID-ROI1>3.0.CO;2-X.

Abstract

We have investigated whether a hydrophilic photosensitizer, chlorin e6Na (Ce6Na), can sensitize cells to ionizing radiation. When V79-1 cells were pretreated with Ce6Na for 2 hr before receiving a dose of 2-14 Gy of irradiation, the cells became sensitive to X-irradiation. The sensitizing effect of Ce6Na depended on the dose of Ce6Na. The sensitizing effect also depended on the length of the treatment period before X-irradiation up to 4 hr, but not on the length of a treatment period after X-irradiation. Intracellular concentrations of Ce6Na were increased linearly after incubation with Ce6Na for periods of up to 4 h. The dose-modifying factor calculated from the survival curve was 1.25.

MeSH terms

  • Animals
  • Cells, Cultured
  • Cricetinae
  • Cricetulus
  • Fibroblasts / drug effects*
  • Fibroblasts / radiation effects*
  • Lung / cytology
  • Porphyrins / pharmacology*
  • Radiation, Ionizing
  • Radiation-Sensitizing Agents / pharmacology*
  • X-Rays / adverse effects

Substances

  • Porphyrins
  • Radiation-Sensitizing Agents
  • phytochlorin