Asymmetric spin-echo imaging of magnetically inhomogeneous systems: theory, experiment, and numerical studies

Magn Reson Med. 1998 Sep;40(3):432-42. doi: 10.1002/mrm.1910400314.


The ability of the asymmetric spin-echo (ASE) pulse sequence to provide different degrees of spin-echo (SE)-type and gradient-echo (GE)-type contrast when imaging media containing magnetic inhomogeneities is investigated. The dependence of the ASE signal on the size of magnetic field perturbers is examined using theory, computer simulations, and experiment. A theoretical prediction of the ASE signal is obtained using the Anderson-Weiss mean field theory, the results of which are qualitatively supported by computer simulations and experimental studies. It is shown that the ASE sequence can be used to tune the range of perturber sizes that provide the largest contributions to susceptibility contrast effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Artifacts
  • Computer Simulation
  • Echo-Planar Imaging / instrumentation*
  • Humans
  • Image Enhancement / instrumentation
  • Magnetic Resonance Imaging / instrumentation*
  • Monte Carlo Method
  • Phantoms, Imaging
  • Spin Labels


  • Spin Labels