Ex vivo tissue-type independence in proton-resonance frequency shift MR thermometry

Magn Reson Med. 1998 Sep;40(3):454-9. doi: 10.1002/mrm.1910400316.


The temperature sensitivity of the proton-resonance frequency (PRF) has proven valuable for the monitoring of MR image-guided thermal coagulation therapy. However, there is significant inconsistency in reported values of the PRF-thermal coefficient, as measured from experiments encompassing a range of in vivo and ex vivo tissue types and experimental conditions. A method of calibrating the temperature dependence of the PRF is described and results are presented that indicate a tissue-type independence. To this end, other possible mechanisms for variations in the PRF-thermal coefficient are suggested, including physiological perturbations and volume magnetic susceptibility effects from geometry and orientation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calibration
  • Computer Systems
  • Humans
  • Hyperthermia, Induced / instrumentation*
  • Magnetic Resonance Imaging / instrumentation*
  • Magnetic Resonance Spectroscopy / instrumentation*
  • Phantoms, Imaging
  • Rabbits
  • Swine
  • Thermometers*