Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1998 Sep;275(3):F319-24.
doi: 10.1152/ajprenal.1998.275.3.F319.

Urea Transporters in Kidney: Molecular Analysis and Contribution to the Urinary Concentrating process1

Affiliations
Review

Urea Transporters in Kidney: Molecular Analysis and Contribution to the Urinary Concentrating process1

H Tsukaguchi et al. Am J Physiol. .

Abstract

Facilitated urea transporters (UTs) are responsible for urea accumulation in the renal inner medulla of the mammalian kidney and therefore play a central role in the urinary concentrating process. Recently, the cDNAs encoding three members of the UT family, UT1, UT2, and UT3 have been cloned. These transporters are expressed in different structures of the mammalian kidney. In rat, UT1 resides in the apical membrane of terminal inner medullary collecting ducts, where it mediates vasopressin-regulated urea reabsorption. UT2 and UT3 are located in descending thin limbs of Henle's loop and descending vasa recta, respectively, and participate in urinary recycling processes, which minimize urea escape from the inner medulla. UT1 and UT2 are regulated independently and respond differently to changes in dietary protein content and hydration state. Identification and characterization of these urea transporters advances our understanding of the molecular basis and regulation of the urinary concentrating mechanism.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

LinkOut - more resources

Feedback