Ras--a versatile cellular switch

Curr Opin Genet Dev. 1998 Aug;8(4):412-8. doi: 10.1016/s0959-437x(98)80111-1.

Abstract

With the number of known roles played by Ras proteins increasing rapidly, finding answers to how the diverse cellular responses are triggered is becoming increasingly pertinent. Although our understanding of the control of specificity of signal transduction is still small, the combination of biochemical, structural and genetic analyses is starting to reveal how the cell-specific responses to Ras activation are controlled.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Enzyme Activation
  • Phosphatidylinositol 3-Kinases / metabolism
  • Proto-Oncogene Proteins c-raf / metabolism
  • Signal Transduction*
  • ras Proteins / physiology*

Substances

  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-raf
  • ras Proteins