BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

Curr Opin Genet Dev. 1998 Aug;8(4):443-9. doi: 10.1016/s0959-437x(98)80116-0.


Bone morphogenetic (BMPs), members of the TGF-beta superfamily, have critical functions in many biological contexts. Recent findings in Drosophila and vertebrates suggest that BMP signaling can be modulated extracellularly and intracellularly by the availability of BMP inhibitors and Smads, respectively.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism*
  • Metalloendopeptidases / metabolism*
  • Signal Transduction*
  • Transforming Growth Factor beta / metabolism*


  • Bone Morphogenetic Proteins
  • Transforming Growth Factor beta
  • Metalloendopeptidases