New players and puzzles in the Hedgehog signaling pathway

Curr Opin Genet Dev. 1998 Aug;8(4):450-6. doi: 10.1016/s0959-437x(98)80117-2.


Members of the Hedgehog (Hh) family of signaling proteins control cell fates and proliferation during animal development in part by regulating the transcription of specific genes. Depending on the tissue, Hh can act over long or short distances, to signal directly or by inducing secondary signals. Recent discoveries include new components of the pathway as well as novel regulatory mechanisms involving cholesterol, proteolysis, and the cytoskeleton. The role of Hh in carcinogenesis is underscored by the identification of mutations in several pathway components in skin and brain tumors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cholesterol / metabolism
  • Drosophila Proteins*
  • Hedgehog Proteins
  • Humans
  • Insect Proteins / metabolism*
  • Membrane Proteins / metabolism
  • Nuclear Proteins / metabolism
  • Patched Receptors
  • Proteins / metabolism*
  • Proteins / physiology
  • Receptors, Cell Surface
  • Signal Transduction*
  • Trans-Activators*
  • Transcription, Genetic


  • Drosophila Proteins
  • Hedgehog Proteins
  • Insect Proteins
  • Membrane Proteins
  • Nuclear Proteins
  • Patched Receptors
  • Proteins
  • Receptors, Cell Surface
  • Trans-Activators
  • ptc protein, Drosophila
  • hh protein, Drosophila
  • Cholesterol