Predictors of work injuries were studied in a sample of employed adolescents. The 20 predictors comprise 5 general categories of risk factors: demographic, personality, employment, health, and substance use. Data were obtained from a sample of 319 individuals ages 16 to 19. Hierarchical regression analysis revealed that all 5 categories of risk factors were related to job injuries. The significant predictors of work injuries among adolescents were gender, negative affectivity, job tenure, exposure to physical hazards, excessive workloads, job boredom, poor physical health, and on-the-job substance use.