Abstract
We examined the effects of caffeic acid-containing compounds such as chlorogenic acid, rosmarinic acid and rabdosiin on anti-allergic activities involving active oxygens scavenging activity as well as inhibitory activities of hyaluronidase and beta-hexosaminidase release. Rabdosiin exhibited the highest hyaluronidase-inhibitory activity and scavenging activities against active oxygens species such as superoxide anion radicals and hydroxyl radicals among the tested compounds. Both rabdosiin and caffeic acid inhibited beta-hexosaminidase release from cultured cells more than 90% at 2 mM. The inhibition by rosmarinic acid and chlorogenic acid were weaker than that of rabdosiin. From these results, rabdosiin has been proposed to possess anti-allergic activity.
MeSH terms
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Animals
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Anti-Allergic Agents / pharmacology*
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Caffeic Acids / pharmacology*
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Chlorogenic Acid / pharmacology
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Cinnamates / pharmacology
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Depsides
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Electron Spin Resonance Spectroscopy
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Enzyme Inhibitors / pharmacology*
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Free Radical Scavengers / pharmacology*
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Hyaluronoglucosaminidase / antagonists & inhibitors
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Hydroxyl Radical / metabolism
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Leukemia, Basophilic, Acute / enzymology
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Leukemia, Basophilic, Acute / pathology
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Lignans
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Rats
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Rosmarinic Acid
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Superoxides / metabolism
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Tumor Cells, Cultured
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beta-N-Acetylhexosaminidases / antagonists & inhibitors
Substances
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Anti-Allergic Agents
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Caffeic Acids
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Cinnamates
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Depsides
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Enzyme Inhibitors
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Free Radical Scavengers
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Lignans
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rabdosiin
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Superoxides
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Chlorogenic Acid
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Hydroxyl Radical
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Hyaluronoglucosaminidase
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beta-N-Acetylhexosaminidases