MRI in acute disseminated encephalomyelitis following Semple antirabies vaccine

Neuroradiology. 1998 Jul;40(7):420-3. doi: 10.1007/s002340050615.


I reviewed MRI findings in five patients with acute disseminated encephalomyelitis following vaccination with Semple antirabies vaccine. MRI in two patients with encephalitis features showed multiple white matter lesions in the cerebrum, cerebellar peduncles and brain stem. Two patients who had features of cord involvement showed signal alterations in the cord extending over a few segments. Asymptomatic lesions in the cerebrum were seen in two patients. In a patient with encephalomyelitis MRI 50 days later showed resolution of the lesions. The white matter lesions described were indistinguishable from those seen in acute disseminated encephalomyelitis following other infections.

MeSH terms

  • Adult
  • Brain / pathology
  • Encephalomyelitis, Acute Disseminated / pathology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Rabies Vaccines / adverse effects*
  • Spinal Cord / pathology


  • Rabies Vaccines