Effects of amphetamine and phenylethylamine on catecholamine release in the glomerular layer of the rat olfactory bulb

Biol Signals Recept. Jul-Aug 1998;7(4):235-43. doi: 10.1159/000014548.

Abstract

In the present work, we have shown electrochemically that in the rat olfactory bulb (OB), extracellular dopamine (DA) was highest in the glomerular layer (GL), whereas extracellular noradrenaline (NA) appeared to be more uniformly distributed across layers. The GL catecholamine (CA) responses to amphetamine (AMPH) and phenylethylamine (PEA) were also characterized electrochemically using an in vivo model. Results of this investigation show that at a lower dose (1 mg/kg), PEA had no effect on CA release. In contrast, at a higher dose (10 mg/kg), it produced similar increases in either extracellular DA (17.5 +/- 7%) or extracellular NA (14 +/- 3%), and DA exhibited dose-independent increases to AMPH (93 +/- 8%: 1 mg/kg vs. 97 +/- 6%: 10 mg/kg) whereas NA exhibited dose-dependent increases to AMPH (24.5 +/- 6%: 1 mg/kg vs. 39 +/- 7%: 10 mg/kg). These data indicate that (i) PEA may increase CA release but less efficiently than AMPH. (ii) AMPH is more efficient on the DAergic than on the NAergic system since AMPH-induced DA release exceeded 2-4 times the AMPH-induced NA release.

Publication types

  • Comparative Study

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Dopamine / metabolism*
  • Dose-Response Relationship, Drug
  • Male
  • Neurons / metabolism
  • Norepinephrine / metabolism*
  • Olfactory Bulb / drug effects*
  • Olfactory Bulb / metabolism
  • Olfactory Bulb / ultrastructure
  • Phenethylamines / pharmacology*
  • Rats
  • Rats, Wistar

Substances

  • Phenethylamines
  • phenethylamine
  • Amphetamine
  • Dopamine
  • Norepinephrine