Beta-blockers for chronic heart failure: from prejudice to enlightenment

J Cardiovasc Pharmacol. 1998:32 Suppl 1:S52-60. doi: 10.1097/00005344-199800003-00009.

Abstract

Experience accumulated from several large trials strongly suggest that beta-blockers should be used for the management of congestive heart failure (CHF). Beta-blockade should be added to conventional therapy such as diuretics, ACE inhibitors, and digoxin, as this was the approach used in the major trials. It is appropriate to treat patients with mild, moderate and, when stable, severe CHF. The benefits obtained include improvements in left ventricular function, reductions in symptoms and morbidity, improvement of quality of life, and delay of clinical progression, reflected by a reduced need for hospitalization and a reduction in mortality. Beta-blockers are much better tolerated, when used appropriately in selected patients, than was previously supposed.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects
  • Adrenergic beta-Antagonists / therapeutic use*
  • Asthma / complications
  • Asthma / drug therapy
  • Contraindications
  • Exercise Test
  • Heart Failure / complications
  • Heart Failure / drug therapy*
  • Heart Failure / mortality
  • Humans
  • Hypertension / complications
  • Hypertension / drug therapy
  • Myocardial Infarction / complications
  • Myocardial Infarction / drug therapy
  • Quality of Life
  • Ventricular Dysfunction

Substances

  • Adrenergic beta-Antagonists