Ibuprofen-induced hepatotoxicity in patients with chronic hepatitis C: a case series

Am J Gastroenterol. 1998 Sep;93(9):1563-5. doi: 10.1111/j.1572-0241.1998.00484.x.


Hepatitis C is a common chronic infection. Nonsteroidal anti-inflammatory drugs are commonly ingested both over-the-counter and by prescription. This case report describes three cases where ibuprofen use leads to a marked rise in hepatic transaminases with one case repeating on rechallenge. These cases support the recommendation of acetaminophen over nonsteroidal antiinflammatory drug use in patients with chronic hepatitis C.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alanine Transaminase / blood
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspartate Aminotransferases / blood
  • Chemical and Drug Induced Liver Injury / diagnosis
  • Chemical and Drug Induced Liver Injury / etiology*
  • Clinical Enzyme Tests
  • Hepatitis C, Chronic / complications*
  • Humans
  • Ibuprofen / adverse effects*
  • Male


  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Ibuprofen