Oxidative stress in subjects affected by celiac disease

Free Radic Res. 1998 Jul;29(1):17-24. doi: 10.1080/10715769800300031.


In order to study the role of oxidative stress in celiac disease, protein carbonyl groups, thiobarbituric acid-reactive substance and pentosidine were evaluated in the plasma of nine patients with asymptomatic celiac disease and in a control group (n = 25). Plasma alpha-tocopherol, retinol and lipids were determined in the same samples. The levels of markers of oxidative stress derived from both protein (carbonyl groups) and lipids (thiobarbituric acid-reactive substances) were significantly higher in celiac disease patients, whereas lipoproteins and alpha-tocopherol were significantly lower. These data indicate that in celiac disease, even when asymptomatic, a redox imbalance persists; this is probably caused by an absorption deficiency, even if slight. Dietary supplementation with antioxidant molecules may offer some benefit and deserves further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Arginine / analogs & derivatives
  • Arginine / blood
  • Blood Proteins / analysis*
  • Blood Proteins / chemistry
  • Case-Control Studies
  • Celiac Disease / metabolism*
  • Female
  • Humans
  • Lipids / blood
  • Lysine / analogs & derivatives
  • Lysine / blood
  • Male
  • Oxidative Stress*
  • Thiobarbituric Acid Reactive Substances / analysis*
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Vitamin A / blood
  • Vitamin E / blood*


  • Blood Proteins
  • Lipids
  • Thiobarbituric Acid Reactive Substances
  • Vitamin A
  • Vitamin E
  • Arginine
  • pentosidine
  • Lysine