Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

Mol Cell. 1998 Aug;2(2):275-81. doi: 10.1016/s1097-2765(00)80139-2.


Recruitment of blood monocytes into the arterial subendothelium is one of the earliest steps in atherogenesis. Monocyte chemoattractant protein-1 (MCP-1), a CC chemokine, is one likely signal involved in this process. To test MCP-1's role in atherogenesis, low density lipoprotein (LDL) receptor-deficient mice were made genetically deficient for MCP-1 and fed a high cholesterol diet. Despite having the same amount of total and fractionated serum cholesterol as LDL receptor-deficient mice with wild-type MCP-1 alleles, LDL receptor/MCP-1-deficient mice had 83% less lipid deposition throughout their aortas. Consistent with MCP-1 's monocyte chemoattractant properties, compound-deficient mice also had fewer macrophages in their aortic walls. Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta / metabolism
  • Aorta / pathology
  • Arteriosclerosis / etiology
  • Arteriosclerosis / physiopathology
  • Arteriosclerosis / prevention & control*
  • Base Sequence
  • Cell Movement
  • Chemokine CCL2 / deficiency*
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / physiology
  • DNA Primers / genetics
  • Diet, Atherogenic
  • Female
  • Lipid Metabolism
  • Lipids / blood
  • Macrophages / pathology
  • Macrophages / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Monocytes / physiology
  • Polymerase Chain Reaction
  • Receptors, LDL / deficiency*


  • Chemokine CCL2
  • DNA Primers
  • Lipids
  • Receptors, LDL