Identification of a new human immunodeficiency virus type 1 distinct from group M and group O

Nat Med. 1998 Sep;4(9):1032-7. doi: 10.1038/2017.


A highly divergent HIV-1 isolate, designated YBF 30, was obtained in 1995 from a 40-year-old Cameroonian woman with AIDS. Depending on the genes studied, phylogenetic analysis showed that YBF30 branched either with SIVcpz-gab or between SIVcpz-gab and HIV-1 group M. The structural genes and tat, vpr, and nef of YBF30 are approximately equidistant from those of HIV-1 group M and SIVcpz-gab. In contrast, vif and rev are closer to HIV-1 group M, and vpu is highly divergent. Using a YBF30 V3 loop peptide enzyme immunoassay, we screened 700 HIV-1-positive sera collected in Cameroon; three reacted strongly with the YBF30 peptides and one was confirmed as being related to YBF30 by genetic analysis of a pol fragment. YBF30 is as distinct from SIVcpz-gab as it is from HIV-1 group M and can thus be considered as the prototype strain of a new human immunodeficiency virus group.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Acquired Immunodeficiency Syndrome / virology*
  • Adult
  • Amino Acid Sequence
  • Base Sequence
  • Cameroon / epidemiology
  • DNA, Viral
  • Female
  • Genome, Viral
  • HIV-1 / classification
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • HIV-1 / metabolism
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Receptors, CCR5 / metabolism
  • Simian Immunodeficiency Virus / classification
  • Simian Immunodeficiency Virus / genetics


  • DNA, Viral
  • Receptors, CCR5

Associated data

  • GENBANK/AJ006022