Abstract
The rationale for a multifaceted operative procedure in all MEN 1 patients with pancreaticoduodenal neuroendocrine disease who present without liver metastases is presented. The results in 36 patients with MEN 1 ZES are encouraging in that more than two-thirds are eugastrinemic and none have liver metastases after follow-up as long as 20 years.
MeSH terms
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Adult
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Duodenal Neoplasms / diagnostic imaging
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Duodenal Neoplasms / surgery*
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Female
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Follow-Up Studies
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Gastrins / antagonists & inhibitors
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Hormones
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Humans
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Liver Neoplasms / secondary
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Male
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Mass Screening
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Multiple Endocrine Neoplasia Type 1 / surgery*
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Neuroendocrine Tumors / diagnostic imaging
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Neuroendocrine Tumors / secondary
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Neuroendocrine Tumors / surgery*
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Octreotide
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Pancreatectomy
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Pancreatic Neoplasms / diagnostic imaging
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Pancreatic Neoplasms / surgery*
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Radionuclide Imaging
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Radiopharmaceuticals
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Zollinger-Ellison Syndrome / surgery
Substances
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Gastrins
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Hormones
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Radiopharmaceuticals
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Octreotide