Experimental infection of the human granulocytic ehrlichiosis agent in horses

Vet Parasitol. 1998 Jul 31;78(2):137-45. doi: 10.1016/s0304-4017(98)00133-2.

Abstract

Human blood collected from two patients from Westchester County, New York with human granulocytic ehrlichia (HGE) infection was inoculated into two ponies. Inoculated ponies developed clinical signs similar to a previous report (Madigan et al., 1995). Histopathological changes involved follicular hyperplasia of lymphoid tissues. HGE DNA was detected by PCR in muscle, fascia, peritoneum, and adrenal gland after the ponies produced a high level of antibodies to HGE. We suggest that HGE may reside in poorly vascularized connective tissues, where the antibodies may have some difficulties to penetrate, resulting in persistent infection. Since HGE and E. equi cause very similar diseases in both humans and horses, they may be the same organism with minor genetic differences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / microbiology
  • Adrenal Glands / pathology
  • Aged
  • Animals
  • DNA, Bacterial / analysis
  • DNA, Bacterial / blood
  • Ehrlichia / classification
  • Ehrlichia / genetics
  • Ehrlichia / physiology*
  • Ehrlichiosis / microbiology
  • Ehrlichiosis / pathology
  • Ehrlichiosis / veterinary*
  • Fascia / microbiology
  • Fascia / pathology
  • Horse Diseases / microbiology*
  • Horse Diseases / pathology
  • Horses
  • Humans
  • Joints / microbiology
  • Joints / pathology
  • Liver / pathology
  • Lung / microbiology
  • Lung / pathology
  • Lymph Nodes / microbiology
  • Lymph Nodes / pathology
  • Lymphatic System / pathology
  • Male
  • Middle Aged
  • Muscle, Skeletal / microbiology
  • Muscle, Skeletal / pathology
  • Peritoneum / microbiology
  • Peritoneum / pathology
  • Polymerase Chain Reaction / veterinary
  • Specific Pathogen-Free Organisms
  • Spleen / pathology

Substances

  • DNA, Bacterial