Antisense therapeutics

Curr Opin Chem Biol. 1998 Aug;2(4):519-28. doi: 10.1016/s1367-5931(98)80129-4.


The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway. Questions regarding the specificity of action and side effects of antisense phosphorothioate oligonucleotides have arisen simultaneously.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • Drug Design
  • Drug Therapy, Combination
  • Humans
  • Oligonucleotides, Antisense / pharmacokinetics
  • Oligonucleotides, Antisense / therapeutic use*
  • Oligonucleotides, Antisense / toxicity
  • Thionucleotides / pharmacokinetics
  • Thionucleotides / therapeutic use*
  • Thionucleotides / toxicity
  • Tissue Distribution


  • Antineoplastic Agents
  • Antiviral Agents
  • Oligonucleotides, Antisense
  • Thionucleotides