Molecular Pathology of Ovarian Carcinomas

Virchows Arch. 1998 Aug;433(2):103-11. doi: 10.1007/s004280050224.

Abstract

There is evidence that ovarian cancer may be derived from the progressive transformation of benign and/or borderline tumours. Mutations involving different oncogenes and tumour suppressor genes accumulate during the process of malignant transformation, and the alterations of genes involved in the pathogenesis of familial ovarian cancer are probably early events in ovarian tumorigenesis. BRCA-1 and BRCA-2 act as classical tumour suppressor genes in hereditary tumours, but their role in sporadic tumours remains controversial; however, a high frequency of allele losses in BRCA-1 (17q) and BRCA-2 (13q) loci has been observed in both familial and sporadic tumours. The possible role of mismatch repair genes and microsatellite instability is also controversial, but a role for them has been proposed in borderline tumours. Mutations in K-ras are specific for mucinous tumours and may be related to mucinous differentiation. Finally, a role in tumour progression has been proposed for both c-erb B-2 and p53, but their practical value in prognosis remains questionable.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • BRCA2 Protein
  • Cyclins / genetics
  • Female
  • Genes, BRCA1
  • Genes, erbB-2
  • Genes, p53
  • Genes, ras
  • Humans
  • Microsatellite Repeats
  • Mutation*
  • Neoplasm Proteins / genetics
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Transcription Factors / genetics

Substances

  • BRCA2 Protein
  • Cyclins
  • Neoplasm Proteins
  • Transcription Factors