Autoimmunity in diabetic autonomic neuropathy: does the immune system get on your nerves?

Diabet Med. 1998 Sep;15(9):723-9. doi: 10.1002/(SICI)1096-9136(199809)15:9<723::AID-DIA674>3.0.CO;2-7.


Symptomatic autonomic neuropathy is a devastating occasional complication of diabetes mellitus, especially Type 1. Although the full-blown clinical syndrome is not common, dysfunction of the autonomic nerves is detectable in up to 40% of Type 1 diabetic patients but its aetiopathogenesis is poorly understood. There is evidence to suggest that the damage to the autonomic nerves may be immune-mediated. This evidence is reviewed in the following article.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmunity*
  • Autonomic Nervous System Diseases / immunology*
  • Diabetic Neuropathies / immunology*
  • Humans
  • Immune System / immunology