Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Aug;42(2):211-6.
doi: 10.1093/jac/42.2.211.

The Effect of a Component of Tea (Camellia Sinensis) on Methicillin Resistance, PBP2' Synthesis, and Beta-Lactamase Production in Staphylococcus Aureus

Affiliations

The Effect of a Component of Tea (Camellia Sinensis) on Methicillin Resistance, PBP2' Synthesis, and Beta-Lactamase Production in Staphylococcus Aureus

T S Yam et al. J Antimicrob Chemother. .

Abstract

Extracts of tea (Camellia sinensis) can reverse methicillin resistance in methicillin-resistant Staphylococcus aureus (MRSA) and also, to some extent, penicillin resistance in beta-lactamase-producing S. aureus. These phenomena are explained by prevention of PBP2' synthesis and inhibition of secretion of beta-lactamase, respectively. Synergy between beta-lactams and tea extracts were demonstrated by disc diffusion, chequerboard titration and growth curves. Partition chromatography of an extract of green tea on Sephadex LH-20 yielded several fractions, one of which contained a virtually pure compound that showed the above-mentioned activities, at concentrations above about 2 mg/L. The observed activities are novel and distinct from the previously reported direct antibacterial activity of tea extracts. Prevention of PBP2' synthesis offers an interesting possible new approach for the treatment of infections caused by MRSA.

Similar articles

See all similar articles

Cited by 32 articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback