Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA

Jpn J Cancer Res. 1998 Jul;89(7):691-5. doi: 10.1111/j.1349-7006.1998.tb03272.x.


The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Adult
  • Aged
  • Aged, 80 and over
  • DNA / metabolism*
  • DNA Damage
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / analysis
  • Female
  • Humans
  • Lung / metabolism*
  • Lung Neoplasms / metabolism*
  • Male
  • Middle Aged
  • Reactive Oxygen Species


  • Reactive Oxygen Species
  • 8-Hydroxy-2'-Deoxyguanosine
  • DNA
  • Deoxyguanosine