The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment

Br J Clin Pharmacol. 1976 Feb;3(1):123-34. doi: 10.1111/j.1365-2125.1976.tb00579.x.


1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate. 2 Pharmacokinetic assessment of the data indicated no significant intra-subject changes in kinetic parameters before or after chronic treatment with ephedrine HCl (11 mg three times a day) alone or in combination. 3 Tolerance to these therapeutic doses, if it occurs, is therefore not disposition-related but rather to pharmacodynamic changes.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adult
  • Asthma / drug therapy*
  • Biological Availability
  • Drug Therapy, Combination
  • Drug Tolerance
  • Ephedrine / blood
  • Ephedrine / pharmacology
  • Ephedrine / therapeutic use*
  • Female
  • Half-Life
  • Humans
  • Male
  • Middle Aged
  • Phenobarbital / therapeutic use
  • Theophylline / therapeutic use


  • Theophylline
  • Ephedrine
  • Phenobarbital