The Papillomavirus E6 Proteins

Biochim Biophys Acta. 1998 Aug 19;1378(1):F1-19. doi: 10.1016/s0304-419x(98)00009-2.


Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Apoptosis / physiology*
  • Base Sequence
  • Cell Transformation, Viral
  • Humans
  • Molecular Sequence Data
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / physiology*
  • Papillomavirus E7 Proteins
  • Repressor Proteins*
  • Telomerase / metabolism
  • Transcriptional Activation*
  • Tumor Suppressor Protein p53 / metabolism


  • E6 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Repressor Proteins
  • Tumor Suppressor Protein p53
  • oncogene protein E7, Bovine papillomavirus type 1
  • oncogene protein E7, Human papillomavirus type 16
  • Telomerase