Signal transduction via platelet-derived growth factor receptors

Biochim Biophys Acta. 1998 Aug 19;1378(1):F79-113. doi: 10.1016/s0304-419x(98)00015-8.


Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different signaling pathways are initiated leading to cell growth, actin reorganization migration and differentiation. Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel.

Publication types

  • Review

MeSH terms

  • Cell Division
  • Cell Movement
  • Dimerization
  • Feedback
  • Integrins / physiology
  • Phosphorylation
  • Platelet-Derived Growth Factor / antagonists & inhibitors
  • Platelet-Derived Growth Factor / physiology*
  • Receptors, Platelet-Derived Growth Factor / physiology*
  • Signal Transduction / physiology*


  • Integrins
  • Platelet-Derived Growth Factor
  • Receptors, Platelet-Derived Growth Factor