In healthy individuals, every physiologic and metabolic process is controlled by more or less complex manners. One of the best control mechanism is the way of excreting excess of CO2. The maintenance of artificial breathing compromises or completely disturbs the above process which exposes the body to an adverse effect of high paCO2. The possible causes leading to the increase in paCO2 during general anesthesia with the use of endotracheal intubation were discussed in the work.