Dipole source localization by means of maximum likelihood estimation. II. Experimental evaluation

Electroencephalogr Clin Neurophysiol. 1998 Apr;106(4):322-9. doi: 10.1016/s0013-4694(97)00139-9.


A dipole source analysis of repeated measurements of the auditory evoked field (AEF) elicited by 60 dB SL tonebursts confirmed the previous theoretical prediction that a maximum likelihood estimation technique reduces localization errors resulting from noise in the measured data by about a factor of two as compared to the common least-squares fit procedure. To achieve a comparable improvement by averaging independent epochs (Gaussian noise assumed), the number of averages would have to be increased by a factor of 4. Conversely, the measurement time required to achieve a given localization accuracy could be reduced by that factor.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Electric Stimulation
  • Evoked Potentials, Auditory / physiology
  • Female
  • Humans
  • Least-Squares Analysis
  • Magnetoencephalography / statistics & numerical data*
  • Male