Influence of oxytocin and meperidine on the isolated human umbilical artery

Biol Neonate. 1976;29(5-6):333-42. doi: 10.1159/000240883.


The influence of oxytocin and meperidine on responses of the isolated umbilical artery to acetylcholine (ACh) and/or 5-hydroxytryptamine (5-HT) was investigated. 32 preparations from 21 normal full-term deliveries were utilized. The Bunce double-blade hemostat provided an excellent means to collect cord specimens with the least postpartal changes. A method of simultaneously measuring the resistance to flow and longitudinal tension in the perfused artery was found to be a sensitive way to register functional responses. Results showed that oxytocin enhanced the response of the umbilical artery to ACh and 5-HT while meperidine blocked the constriction produced by 5-HT. Both these effects lasted from 30 min to more than 2 h and were reversible.

MeSH terms

  • Acetylcholine / pharmacology
  • Anesthesia, Obstetrical
  • Female
  • Humans
  • Infant, Newborn
  • Meperidine / pharmacology*
  • Oxytocin / pharmacology*
  • Pregnancy
  • Serotonin / pharmacology
  • Umbilical Arteries / drug effects*
  • Vascular Resistance / drug effects
  • Vasomotor System / drug effects*


  • Serotonin
  • Oxytocin
  • Meperidine
  • Acetylcholine