[A case of pharyngeal-cervical-branchial variant of Guillain-Barré syndrome with IgG anti-GT1a antibody]

Rinsho Shinkeigaku. 1998 Apr;38(4):333-5.
[Article in Japanese]


A 36-year-old man with pharyngeal-cervical-brachial variant of Guillain-Barré syndrome (PCB) was described. Neurologic examination revealed total ophthalmoplegia, pharyngeal-cervical-brachial weakness and hyporeflexia in the upper limbs, sparing power and tendon reflexes in the lower limbs. Enzyme-linked immunosorbent assay showed that he had high titer of IgG antibody to GT1a (1:32,000), which did not cross-react with GQ1 b or GD1a. Thin-layer chromatography immunostaining confirmed that his serum IgG reacted with GT1a. These findings show that IgG anti-GT1a antibody without cross-reactivity with GQ1b plays a role in the development of PCB.

Publication types

  • Case Reports
  • English Abstract
  • Review

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Cross Reactions
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay
  • Gangliosides / immunology*
  • Humans
  • Immunoglobulin G / blood*
  • Male
  • Polyradiculoneuropathy / classification
  • Polyradiculoneuropathy / diagnosis*


  • Autoantibodies
  • Gangliosides
  • Immunoglobulin G