Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae

FEBS Lett. 1998 Sep 4;434(3):219-25. doi: 10.1016/s0014-5793(98)00967-3.


The recent availability of the full Saccharomyces cerevisiae genome sequence offers a first opportunity to analyze the composition, function and evolution of GTPases in the ras-p21 superfamily. This superfamily in yeast is composed of 29 proteins divided into five families: ras with four sequences implicated in cell signalling; rho, six genes related to the cell shape machinery; ypt-rab, ten proteins with different roles in intracellular trafficking; arf-sar, seven proteins related to vesicular trafficking in secretory pathways; and ran, two proteins acting as components of the nuclear transport system. The superfamily covers a wide range of cellular functions from signalling to intracellular trafficking, while conserving the structural framework and a common mechanism of GTP hydrolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Evolution, Molecular
  • GTP Phosphohydrolases / genetics
  • Genome, Fungal*
  • Humans
  • Oncogene Protein p21(ras) / genetics*
  • Saccharomyces cerevisiae / genetics*
  • Schizosaccharomyces / genetics


  • GTP Phosphohydrolases
  • Oncogene Protein p21(ras)