Carnosine, a protective, anti-ageing peptide?

Int J Biochem Cell Biol. 1998 Aug;30(8):863-8. doi: 10.1016/s1357-2725(98)00060-0.

Abstract

Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • Aging*
  • Animals
  • Carnosine / biosynthesis
  • Carnosine / chemistry
  • Carnosine / physiology*
  • Carnosine / therapeutic use
  • Humans
  • Molecular Structure

Substances

  • Carnosine