Systematic functional analysis of the yeast genome

Trends Biotechnol. 1998 Sep;16(9):373-8. doi: 10.1016/s0167-7799(98)01214-1.


The genome sequence of the yeast Saccharomyces cerevisiae has provided the first complete inventory of the working parts of a eukaryotic cell. The challenge is now to discover what each of the gene products does and how they interact in a living yeast cell. Systematic and comprehensive approaches to the elucidation of yeast gene function are discussed and the prospects for the functional genomics of eukaryotic organisms evaluated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Genetic Techniques*
  • Genome, Fungal*
  • Mutagenesis
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / physiology
  • Sequence Deletion
  • Transcription, Genetic