Absorption of cholesterol oxidation products from ordinary foodstuff in humans

Ann Nutr Metab. 1998;42(4):221-30. doi: 10.1159/000012737.

Abstract

Background: Information on the absorption of cholesterol oxidation products (COP) from ordinary foodstuff in humans is scarce.

Methods: Five healthy young men were offered a salami- and Parmesan-containing meal naturally rich in COP. Plasma and lipoprotein COP concentrations were measured over the following 9 h.

Results: The mean plasma free (nonesterified) COP concentration showed its maximal increase 3 and 5 h after meal consumption. In contrast, the raise in plasma total COP concentration began 6 h after the meal with a maximum at 8 h and was statistically significant for 7alpha- and 7beta-hydroxycholesterol and 7-ketocholesterol. The increase in plasma total cholesterol concentration was comparable to that of total COP. Comparing the COP composition of the chylomicrons and the test meal, cholestanetriol, 7-ketocholesterol, and to a lesser extent cholesterol-alpha-epoxide were underrepresented in the chylomicrons as was the opposite for 7beta-hydroxycholesterol. In very-low-density lipoprotein, a steady increase in the COP:cholesterol ratio was observed from 6 h on.

Conclusion: COP from ordinary foodstuff were absorbed in the human intestinal tract but differences in the bioavailability of the single COP compounds were found.

MeSH terms

  • Absorption
  • Adult
  • Cheese
  • Cholesterol / blood
  • Cholesterol / metabolism
  • Cholesterol / pharmacokinetics*
  • Chylomicrons
  • Food*
  • Humans
  • Hydroxycholesterols / pharmacokinetics
  • Ketocholesterols / pharmacokinetics
  • Kinetics
  • Male
  • Meat Products
  • Oxidation-Reduction

Substances

  • Chylomicrons
  • Hydroxycholesterols
  • Ketocholesterols
  • cholest-5-en-3 beta,7 alpha-diol
  • Cholesterol
  • 7-ketocholesterol