Are autoimmune thyroid dysfunction and depression related?

J Clin Endocrinol Metab. 1998 Sep;83(9):3194-7. doi: 10.1210/jcem.83.9.5131.


The objective of this study was to examine the relationship between autoimmune thyroid disease and depression in perimenopausal women. Thyroid function [TSH, free T4, and thyroid peroxidase antibodies (TPO-Ab)] and depression (using the Edinburgh Depression Scale) were assessed cross-sectionally together with other determinants of depression. The subjects were 583 randomly selected perimenopausal women (aged 47-54 yr) from a community cohort of 6846 women. The main outcome measures were the occurrence of thyroid dysfunction (abnormal free T4 and/or TSH or elevated levels of TPO-Ab) and the concomitant presence of depression according to the Edinburgh Depression Scale. Neither biochemical thyroid dysfunction nor menopausal status was related to depression. Apart from several psycho-social determinants (the occurrence of a major life event, a previous episode of depression, or financial problems), an elevated level of TPO-Ab (> or = 100 U/mL) was significantly associated with depression (odds ratio, 3.0, 95% confidence interval, 1.3-6.8). We conclude that women with elevated TPO-Ab levels are especially vulnerable to depression, whereas postmenopausal status does not increase the risk of depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / blood
  • Autoimmune Diseases / psychology*
  • Cohort Studies
  • Depression / immunology*
  • Female
  • Humans
  • Hyperthyroidism / immunology
  • Hyperthyroidism / psychology
  • Hypothyroidism / immunology
  • Hypothyroidism / psychology
  • Iodide Peroxidase / immunology
  • Menopause / psychology*
  • Middle Aged
  • Random Allocation
  • Thyroid Diseases / immunology*
  • Thyroid Diseases / psychology*
  • Thyrotropin / blood
  • Thyroxine / blood


  • Autoantibodies
  • Thyrotropin
  • Iodide Peroxidase
  • Thyroxine