Genetic polymorphisms in Parkinson's disease

Neurotoxicology. Aug-Oct 1998;19(4-5):635-43.

Abstract

The search for genetic polymorphisms relevant to Parkinson's disease etiology and pathogenesis has been motivated by recent thinking emphasizing the potential significance of gene-environment interactions. Especially influential to this research have been the MPTP model of PD induction, hypotheses concerning oxidative stressor reactions, and epidemiological observations of an inverse relation between cigarette smoking and PD risk. This brief review summarizes trends in genetic polymorphism research, with examples provided by investigations of cytochrome P450 enzymes, monoamine oxidase, superoxide dismutase, and mitochondrial genes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • DNA, Mitochondrial / genetics
  • Humans
  • Monoamine Oxidase / genetics
  • Monoamine Oxidase / metabolism
  • Parkinson Disease / enzymology
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics*
  • Polymorphism, Genetic / physiology
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism

Substances

  • DNA, Mitochondrial
  • Cytochrome P-450 Enzyme System
  • Superoxide Dismutase
  • Monoamine Oxidase